Final answer:
The chief reason for the loss of life among Latin American natives in the sixteenth century was the introduction of European diseases to which they had no immunity.
Step-by-step explanation:
The chief reason for the loss of life among Latin American natives in the sixteenth century was the introduction of European diseases to which they had no immunity.
Diseases like smallpox, typhus, measles, bubonic plague, influenza, and salmonella spread rapidly and had devastating effects on the indigenous populations. Lack of exposure to European livestock and malnutrition also weakened their immune systems, making them more susceptible to infectious diseases.