Final answer:
In the case of metabolic acidosis due to salicylate overdose, a nurse should closely monitor for seizures due to increased neuronal excitability and accumulation of acidic metabolites.
Step-by-step explanation:
A nurse monitoring a client with metabolic acidosis due to salicylate overdose should be vigilant for various clinical manifestations. Because salicylates can lead to increased excitability of the nervous system, the nurse should particularly monitor for signs such as seizures. Other features associated with salicylate toxicity and metabolic acidosis may include confusion, nausea, respiratory difficulties, and marked fluctuations in pH levels.
Seizures are a key finding in salicylate overdose due to the drug's effect on the central nervous system and increased neuronal excitability. Salicylate overdose can cause an accumulation of acid metabolites like sulfasalicylic acid, leading to acidemia, and alter enzyme activity, which together can provoke seizures. It's important for healthcare providers to monitor and manage these symptoms promptly to prevent further complications and ensure patient safety.