Final answer:
The disagreements between these two cabinet members led to the establishment of the first U.S. political parties.
Step-by-step explanation:
The disagreements between these two cabinet members led to Option 2: The establishment of the first U.S. political parties. After the ratification of the Constitution, there was a division among the American people regarding the powers of the state and federal governments. This led to the formation of two political factions, the Federalists and the Anti-Federalists, who disagreed on various issues, including the need for a Bill of Rights. The establishment of political parties was a result of these disagreements.