Final answer:
The statement about combination problems is false because combinations involve scenarios where the order of items does not matter. The correct option to make the statement true is to state that the order does not make a difference.
Step-by-step explanation:
The statement that 'Combination problems involve situations in which the order of the items makes a difference' is false. To produce a true statement, it should be rephrased as follows: 'Combination problems involve situations in which the order of the items does not make a difference.'
In mathematics, a combination is a way of selecting items from a collection such that the order of selection does not matter. In contrast, a permutation is a way of selecting items where the order does matter. Therefore, Option 2 is the correct choice to make the given statement true: change "makes a difference" to "does not make a difference".