Final answer:
Insulin does not effectively work with defective cell receptors to facilitate glucose uptake, which is true and indicative of insulin resistance associated with type 2 diabetes.
Step-by-step explanation:
The statement that insulin doesn't work with a cell receptor to open the cell for glucose uptake because there's something wrong with the cell receptors is true. Type 2 diabetes often involves insulin resistance, where insulin receptors are unresponsive or less responsive to insulin. This means that even when insulin is present and binds to its receptor, it does not effectively trigger the glucose channels on the cell membrane to open, leading to an accumulation of glucose in the blood, known as hyperglycemia.
Diabetic individuals can experience a positive feedback loop disruption due to a lack of functional insulin or a decrease in insulin receptor signaling. This pathophysiology, involving defective insulin receptors or antibodies against insulin, can prevent the lowering of blood sugar levels, as illustrated in Graph-B. The insulin receptor, a tyrosine kinase receptor, is crucial for inducing glucose uptake; impairment of its function is linked to diabetes mellitus type 2.