Final answer:
For Neisseria gonorrhoeae, the CDC recommends a first-line treatment with the cephalosporins Ceftriaxone and Cefixime, often in combination with Azithromycin to also cover potential co-infection with Chlamydia trachomatis and to combat antibiotic resistance.
Step-by-step explanation:
The first-line cephalosporins for treating Neisseria gonorrhoeae are Ceftriaxone and Cefixime. The CDC has found that some strains of N. gonorrhoeae have developed resistance to antibiotics including fluoroquinolones, and tetracyclines, making cephalosporins a preferred treatment option.
Due to the possibility of co-infection with Chlamydia trachomatis, a combination therapy of Ceftriaxone and Azithromycin is recommended. This dual regimen helps address both infections as well as limit the further spread of antibiotic resistance.