Final answer:
George and Lennie are fleeing from the town of A) Weed at the start of John Steinbeck's novel Of Mice and Men due to a misunderstanding involving Lennie.
Step-by-step explanation:
The name of the town from which George and Lennie are fleeing at the beginning of the story is A) Weed. This is depicted in John Steinbeck’s novel Of Mice and Men.
The pair is forced to leave Weed due to a misunderstanding that causes Lennie to be accused of an inappropriate act. To escape potential trouble, they head towards a ranch near Soledad.
Understanding these details is key to grasping the context and setting of Steinbeck's narrative.