Final answer:
Jubal, the son of Cain, is known for making musical instruments according to Genesis 4:21, making him the father of all those who play the lyre and pipe.
Step-by-step explanation:
The son of Cain known for making musical instruments is Jubal. According to the Bible, specifically Genesis 4:21, Jubal is described as 'the father of all those who play the lyre and pipe'. Cain's other descendants mentioned in Genesis included Tubal-cain, who was skilled in forging tools out of bronze and iron, and Jabal, who was the ancestor of those who live in tents and raise livestock. Lamech was the father of these three sons.