Final answer:
Enzymes reduce the activation energy and increase reaction rates without changing the reaction's free energy change.
Step-by-step explanation:
Enzymes play a crucial role in biochemical reactions by affecting the activation energy, reaction rates, and free energy change. The correct answer to what enzymes do to activation energy, reaction rates, and free energy change in a chemical reaction is B) Decrease; Increase; no change. Enzymes work by reducing the activation energy needed for a reaction, thereby increasing the reaction rate. However, enzymes do not alter the free energy change (ΔG) of the reaction, meaning they don't change whether a reaction is exergonic (spontaneous) or endergonic (requires energy).