Final answer:
Granzyme A/B prompt the activation of caspases, leading to apoptosis. Through the action of perforins, granzymes can enter target cells and trigger the caspases that dismantle cellular components for a controlled cell death.
Step-by-step explanation:
Granzyme A/B stimulate caspases, which cause apoptosis. Natural Killer (NK) cells and cytotoxic T lymphocytes release granzymes and perforins as part of the immune response. Perforins create pores in the target cell's membrane, allowing granzymes to enter. Once inside, granzymes activate apoptosis by triggering caspases, which are a family of proteases that lead to programmed cell death by dismantling cellular components. This mechanism ensures that abnormal or infected cells are removed, maintaining cellular homeostasis.
Granzyme A/B stimulate Caspases which cause apoptosis. Caspases are proteolytic enzymes that digest cellular proteins. When granzyme A/B are released by activated NK cells or killer T cells, they enter target cells through perforin and induce apoptosis by activating caspases.