Question

Transfer from incoming dendritic cell to resident dendritic cell: What happens to the MHC molecules loaded and what type of naive T cell is activated?

a) MHC molecules are processed for excretion / CD4+ T cell
b) MHC molecules are recycled for future use / CD8+ T cell
c) MHC molecules are presented to B cells / Memory T cell
d) MHC molecules are presented to naive CD8+ T cells

Answer 1

When a dendritic cell transfers antigens to a resident dendritic cell, the resident dendritic cell presents the antigens on its surface using MHC class I molecules. Naive CD8+ T cells are activated by recognizing the MHC class I molecules and interacting with them.

Step-by-step explanation:

When a dendritic cell transfers antigens to a resident dendritic cell, the MHC molecules loaded with the antigens are presented to naive CD8+ T cells. The resident dendritic cell processes the antigens and presents them on its surface using MHC class I molecules. These MHC class I molecules are recognized by the naive CD8+ T cells, leading to their activation.

When antigens are transferred from an incoming dendritic cell to a resident dendritic cell, the MHC (Major Histocompatibility Complex) molecules loaded with the antigenic peptides are presented to naive CD8+ T cells. This process is crucial for the activation of cytotoxic T lymphocytes (CTLs), which are CD8+ T cells. These activated CTLs play a key role in cell-mediated immunity by recognizing and destroying cells infected with intracellular pathogens, such as viruses. This mechanism is known as cross-presentation, where exogenous antigens (antigens from outside the cell) are presented on MHC class I molecules to activate CD8+ T cells.