Final answer:
Helper T cells activate cytotoxic T cells, which express CD8 receptors and release interferons to amplify the immune response.
Step-by-step explanation:
The correct answer to the question "CD8+ T cell activation (3): _______ ________ cells can activate _______- _____ cells to make - and naive CD8 T cells to express - receptors." is c) Helper / Cytotoxic / interferons / CD8. Naive CD4+ T cells (Helper T cells) engage with Major Histocompatibility Complex II (MHC II) molecules on antigen-presenting cells (APCs) and become activated.
These activated helper T cells can then activate B cells to produce antibodies and activate CD8+ T cells (cytotoxic T cells), which become equipped to kill infected cells and express CD8 receptors. These cytotoxic T cells release interferons to amplify the immune response. The naive CD8 T cells are initially activated by the interaction with MHC I molecules on APCs, but their activity and clonal expansion can be greatly enhanced by cytokines and signals from helper T cells.