Final answer:
In 'Grey's Anatomy', George O'Malley cheats on Callie Torres with Izzie Stevens during the third season of the show. Option A
Step-by-step explanation:
The question refers to a plotline in the television show Grey's Anatomy, a medical drama. In the show, the character George O'Malley, played by T.R. Knight, cheats on his wife Callie Torres, played by Sara Ramirez, with Izzie Stevens, a fellow doctor portrayed by Katherine Heigl.
This event occurs during the show's third season and creates significant emotional turbulence amongst the characters, ultimately affecting their relationships and the dynamic of the show. Option A