Final answer:
Madeleine Albright, the first female secretary of state, was the secretary born in Prague. She was a key figure in U.S. foreign policy during Bill Clinton's presidency. Other secretaries like Kissinger, Powell, and Kerry all had significant roles but were not born in Prague.
Step-by-step explanation:
The secretary who was born in Prague is Madeleine Albright. She was the first female secretary of state, nominated by President Bill Clinton and unanimously confirmed by the Senate. This position carries significant responsibilities in shaping and executing U.S. foreign policy. Henry Kissinger, another notable Secretary of State, is best known for his role during the Nixon and Ford administrations, advocating for détente with the Soviet Union and China, as well as engaging in shuttle diplomacy in the Middle East. Colin Powell, who served under George W. Bush, is remembered for his opposition to the Iraq War and his call for UN support for military actions. John Kerry, who served as Secretary of State under President Obama, represented the United States in negotiations such as the Iran Nuclear Agreement. However, none of these secretaries were born in Prague; that distinction belongs solely to Madeleine Albright.