Final answer:
Starting omeprazole would be the most efficient way to improve the patient's symptoms of heartburn and reflux.
Step-by-step explanation:
In the case of the 52-year-old man presenting with heartburn and reflux, the most efficient way to improve his symptoms would be to start omeprazole, option 2. Omeprazole is a proton pump inhibitor (PPI) that reduces the production of stomach acid, which can help alleviate heartburn and prevent reflux. This medication is commonly used to treat gastroesophageal reflux disease (GERD) and can provide significant relief for the patient.