Question

Lady GaBa, a 60 year old female, was admitted to Saint Francis

Hospital for a gram negative septicemia. The patient weighs 56 kg
and is 5'5'' tall. Her SCr is 1.2 mg/dL. She was started on
gentamicin

Answer 1

The calculated creatinine clearance for Lady GaBa is approximately 45 mL/min.

Step-by-step explanation:

Creatinine clearance is a crucial parameter used to assess renal function. It is calculated using the Cockcroft-Gault formula:

`\[ \text{Creatinine Clearance (CrCl)} = \left( \frac{{(140 - \text{age}) * \text{weight}}}{{72 * \text{SCr}}} \right) * \text{0.85} \]`

In this case, Lady GaBa's age is 60 years, weight is 56 kg, and serum creatinine (SCr) is 1.2 mg/dL. Plugging in these values into the formula:

`\[ CrCl = \left( \frac{{(140 - 60) * 56}}{{72 * 1.2}} \right) * 0.85 \]`

After performing the calculations:

CrCl ≈
`\left( \frac{{80 * 56}}{{86.4}} \right) * 0.85 \]`

`\[ CrCl` ≈
`\left( \frac{{4480}}{{86.4}} \right) * 0.85 \]`

CrCl ≈
`\left( 51.8518 \right) * 0.85 \]`

CrCl ≈ 44.084

The result, rounded to the nearest whole number, is approximately 45 mL/min. This indicates Lady GaBa's estimated creatinine clearance.

It's essential to monitor creatinine clearance when administering drugs like gentamicin, as renal function impacts drug clearance. In this case, with a creatinine clearance of 45 mL/min, adjustments to the gentamicin dosage might be necessary to prevent toxicity, ensuring safe and effective treatment for the gram-negative septicemia.

Full Question:

Lady GaBa, a 60 year old female, was admitted to Saint Francis Hospital for a gram negative septicemia. The 1/1 patient weighs 56 kg and is 5'5'' tall. Her SCr is 1.2 mg/dL. She was started on gentamicin therapy. The gentamicin is infused over 30 mins. Calculate this patient's creatinine clearance. (Round your answer to the nearest whole number).