Final answer:
One clue that a medication-induced manic episode may be occurring in a patient with bipolar disorder is if the patient recently began a new retroviral agent for hepatitis.
Step-by-step explanation:
When determining if a medication change or increase is warranted in a patient with known bipolar I disorder, it is important to gather more information. In this case, you suspect a possible medication-induced manic episode. One clue that could support this suspicion is if the patient recently began a new retroviral agent for hepatitis. Medications for hepatitis, such as antiretroviral agents, have been known to trigger manic symptoms in some individuals with bipolar disorder.