Final answer:
Plasma from blood collected in Sodium heparin and Lithium heparin tubes can be used for the analysis of anti-psychotic drugs. Pretreatment of plasma usually involves SPE with appropriate cartridges and the use of Internal Standards like lamivudine or isoniazid for analytical accuracy.
Step-by-step explanation:
Yes, plasma obtained from blood collected in Sodium heparin and Lithium heparin tubes can be used for anti-psychotic drug analysis. For the detection and quantification of various pharmaceuticals, pretreatment protocols such as Solid Phase Extraction (SPE) using cation-exchange or Hydrophilic-Lipophilic Balance (HLB) cartridges are commonly applied to plasma samples. The Internal Standard (IS) method, where a chemically similar substance is added to the sample to improve analytical accuracy and precision, is commonly employed in such analyses.
For example, lamivudine and isoniazid can be used as IS for certain drug analyses in plasma. Samples are then processed, which may include steps such as protein precipitation (PP) with acetonitrile (ACN), quenching with methanol, or using liquid-liquid extraction techniques, depending on the specific assay requirements and the properties of the anti-psychotic drug under examination.
Generally, the choice of anticoagulant in the collection tube (Sodium or Lithium heparin) does not interfere with drug analysis as long as the chosen method for plasma preparation and the analytical technique are compatible with these substances.