Question

Characteristics of a drug such as high molecular weight, high plasma protein binding, high charge, and hydrophilicity tend to trap the drug in the ________ compartment. How does this affect volume of distribution?

Answer 1

Drugs with characteristics such as high molecular weight, high plasma protein binding, high charge, and hydrophilicity tend to be trapped in the bloodstream or vascular compartment, which can affect their volume of distribution.

Step-by-step explanation:

When a drug has high molecular weight, high plasma protein binding, high charge, and hydrophilicity, it tends to be trapped in the bloodstream or vascular compartment. This can limit the drug's ability to cross membrane barriers and distribute to different tissues in the body. As a result, the volume of distribution of the drug may be reduced, meaning that it is primarily confined to the bloodstream rather than being distributed throughout the body.