Question

Tumor cells detach from surroundings by decreasing expression of ______________, adhere to basement membrane by increasing expression of __________, and invade the basement membrane by increasing expression of ___________________.

Answer 1

Tumour cells detach from surroundings by decreasing the expression of adherens junctions, adhere to the basement membrane by increasing the expression of integrins, and invade the basement membrane by increasing the expression of matrix metalloproteinases (MMPs).

Step-by-step explanation:

Tumor cells detach from surroundings by decreasing expression of adherens junctions, adhere to basement membrane by increasing the expression of integrins, and invade the basement membrane by increasing expression of matrix metalloproteinases (MMPs).

Tumor cells detach from their surroundings by decreasing the expression of adherens junctions, which are proteins responsible for forming strong cohesive tissues and binding cells together. They adhere to the basement membrane by increasing the expression of integrins, which are integral membrane proteins that attach cells to the extracellular matrix. Finally, they invade the basement membrane by increasing the expression of MMPs, which are enzymes that degrade the extracellular matrix to allow tumor cells to move through it.