Question

In the lungs, binding of O2 to hemoglobin drives release of ____ and ____ from hemoglobin (Haldane effect).

Answer 1

In the lungs, the binding of O2 to hemoglobin drives the release of CO2 and H+ from hemoglobin in a process known as the Haldane effect.

Step-by-step explanation:

In the lungs, the binding of O2 to hemoglobin drives the release of carbon dioxide (CO2) and H+ from hemoglobin. This phenomenon is known as the Haldane effect.

When oxygen binds to hemoglobin, it causes a conformational change in the structure of hemoglobin, which decreases its affinity for CO2 and H+. As a result, CO2 and H+ are released from hemoglobin and can diffuse out of the erythrocyte and across the respiratory membrane into the air. The Haldane effect is an important mechanism that ensures efficient gas exchange in the lungs by promoting the release of CO2 from hemoglobin where it can be eliminated.