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Kindling, is defined, as: The tendency of some regions of the brain to react to repeated low-level bioelectrical stimulation by progressively boosting synaptic discharges, thereby lowering seizure thresholds.

User Heizar
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Final answer:

Kindling is a process related to the heightened reactivity of brain regions that can lead to lowered seizure thresholds and contribute to epilepsy, a neurological disorder with recurrent seizures. Treatments for epilepsy often include anticonvulsant medications, and in severe cases, surgical procedures.

Step-by-step explanation:

Kindling in the context of epilepsy refers to the process where repeated low-level stimulation causes certain brain regions to increase their synaptic discharges progressively, thus lowering the seizure threshold. This biological phenomenon can eventually lead to the development of epilepsy, a neurological disorder characterized by recurrent seizures. These epileptic seizures are the result of excessive and abnormal neuronal activity in the cortex of the brain.



In epilepsy, the excitation of neurons can lead to an excitatory postsynaptic potential (EPSP), where there is a depolarization of the postsynaptic neuronal membrane. This is typically caused by the release of neurotransmitters from a presynaptic neuron.


The development of epilepsy can sometimes be attributed to genetic and environmental factors; it is frequently treated with anticonvulsant medications though severe cases may require surgical intervention to remove the seizure-originating brain regions. The kindling effect can also be observed in neuroplastic changes like Long-term Potentiation (LTP), where the synaptic strength between neurons increases over time due to persistent stimulation.

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