42.3k views
3 votes
What is the mechanism of action of Clavulanic Acid and Tazobactam?

User S Haque
by
8.2k points

1 Answer

3 votes

Final answer:

Clavulanic acid and tazobactam are β-lactamase inhibitors that protect and enhance the activity of β-lactam antibiotics by binding to and inhibiting the β-lactamase enzyme.

Step-by-step explanation:

Clavulanic acid and tazobactam are both β-lactamase inhibitors, designed to overcome resistance to β-lactam antibiotics. They work by irreversibly binding to the active site of the β-lactamase enzyme, which is produced by bacteria and degrades the β-lactam ring of the antibiotics, rendering them ineffective. By inhibiting β-lactamase, clavulanic acid and tazobactam protect and enhance the activity of β-lactam antibiotics, such as amoxicillin.

User Methodin
by
8.6k points