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Does facilitated diffusion always have to be in the direction of the electrochemical gradient of the molecule being transported?

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Final answer:

Facilitated diffusion does not always have to be in the direction of the electrochemical gradient of the molecule being transported. It can also occur against the concentration gradient when coupled with the movement of another molecule.

Step-by-step explanation:

Facilitated diffusion does not always have to be in the direction of the electrochemical gradient of the molecule being transported. While facilitated diffusion generally occurs down the concentration gradient, there are some cases where facilitated diffusion can occur against the concentration gradient, meaning it can move the molecule from an area of lower concentration to an area of higher concentration. This happens when the movement of one molecule down its concentration gradient is coupled with the simultaneous movement of another molecule against its concentration gradient.

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