Final answer:
The number of neutrophils increases during inflammation and they are released from the bone marrow. They migrate to the site of infection or inflammation, where they act as efficient phagocytes, helping to fight off pathogens.
Step-by-step explanation:
Neutrophil Increase During Inflammation
In the event of an infection or inflammation, the number of neutrophils increases rapidly as part of the immune response. These neutrophils are released primarily from the bone marrow, where they are stored and rapidly mobilized into the bloodstream. In response to signals like cytokines and leukotrienes, which are released at the site of infection or inflammation, neutrophils are attracted to the site of infection by a process called chemotaxis. Upon reaching the infection site, neutrophils perform their role as efficient phagocytes, using their granules that contain lysozyme, hydrogen peroxide, and defensins to lyse and engulf invading pathogens.
Abnormally high counts of neutrophils, a condition known as neutrophilia, indicate the presence of infection, inflammation, and can also occur in burn patients or those under significant stress. Conversely, low counts of neutrophils, or neutropenia, can increase an individual's susceptibility to infection and may be caused by factors such as drug toxicity or other disorders. The balance and function of neutrophils are critical in the body's defense against infections and in the overall inflammatory process.