Question

Based on data from the Gonococcal Isolate Surveillance Project (GISP), which one of the following statements is TRUE? In recent years, the percentage of isolates with reduced susceptibility to ceftriaxone (defined as MIC ≥0.125 μg/mL) has been approximately 12% In recent years, approximately 15% of gonococcal isolates have reduced susceptibility to cefixime (defined as MIC ≥0.25 μg/mL) In recent years, more than 15% of gonococcal isolates have reduced susceptibility to azithromycin (defined as MIC ≥2 μg/mL) In recent years, more than 10% of gonococcal isolates have been resistant to ciprofloxacin

Answer 1

The true statement about antibiotic resistance in Neisseria gonorrhoeae is that more than 10% of gonococcal isolates have been resistant to ciprofloxacin in recent years, raising concerns about treatment options as cephalosporin resistance also increases.

Step-by-step explanation:

Based on data from the Gonococcal Isolate Surveillance Project (GISP), the TRUE statement regarding antibiotic resistance in Neisseria gonorrhoeae is that in recent years, more than 10% of gonococcal isolates have been resistant to ciprofloxacin.

The Centers for Disease Control and Prevention (CDC) classifies antibiotic resistance in N. gonorrhoeae as an urgent threat and monitors the spread of resistance closely.

As per the information, resistance to tetracycline is most common, but there is also significant concern about resistance to cephalosporins as well as other antibiotics such as azithromycin and ciprofloxacin.

The minimal inhibitory concentration (MIC) is the lowest concentration of an antimicrobial that inhibits visible growth of a bacterium. The CDC recommends combination treatment with ceftriaxone and azithromycin to slow the spread of resistance. However, if resistance to cephalosporins continues to rise, treatment options for N. gonorrhoeae will become increasingly limited.