Final answer:
The most significant consequence of Shays's Rebellion was the involvement of George Washington and the convening of the Constitutional Convention to address the weaknesses of the Articles of Confederation.
Step-by-step explanation:
The most significant consequence of Shays's Rebellion was that it convinced George Washington to come out of retirement and lead the Constitutional Convention.
The rebellion, although quickly put down, highlighted the weaknesses of the Articles of Confederation and the need for a stronger centralized government.
This eventually led to the drafting and ratification of the United States Constitution, which established a more stable and effective government.