Final answer:
A radionuclide thyroid scan would be the most appropriate next step in the management of this patient.
Step-by-step explanation:
The most appropriate next step in the management of this patient would be a Radionuclide thyroid scan (option B). A radionuclide thyroid scan uses a radioactive isotope to evaluate the structure and function of the thyroid gland. This scan can help determine if the mass on the patient's left thyroid lobe is functioning normally or if it is suspicious for thyroid cancer.
Option A (Reassurance) would not be appropriate because a new thyroid mass requires further evaluation. Option C (FNA) may be considered if the scan shows features concerning for malignancy, but it is not the initial step. Option D (Begin PTU) would be more appropriate if the patient had hyperthyroidism, not a thyroid mass. Option E (Total thyroidectomy) is a more invasive option and should be considered after a conclusive diagnosis has been made.