Final answer:
The most likely diagnosis in this patient is a meniscal injury. Symptoms and physical examination findings support this diagnosis. Imaging studies, such as MRI, may be ordered for confirmation.
Step-by-step explanation:
The most likely diagnosis in this patient is a meniscal injury. A meniscal injury occurs when there is a tear in the fibrocartilage pads in the knee, known as the menisci. The symptoms described by the patient, such as a twisting mechanism of injury, sharp pain, swelling, and locking of the knee, are consistent with a meniscal injury.
The physical examination findings also support a meniscal injury, such as tenderness along the medial joint line and an audible click when extending the fully-flexed knee while applying varus stress. The absence of movement of the tibia on the femur when the lower leg is pulled anteriorly at a 90-degree knee flexion further suggests a meniscal injury.
To confirm the diagnosis, imaging studies like MRI may be ordered to visualize the meniscal tear.