Final answer:
The most appropriate intervention would be the placement of an IVC filter.
Step-by-step explanation:
The most appropriate intervention at this time would be E. Placement of an IVC filter.
The patient's symptoms, including pleuritic chest pain, shortness of breath, and large perfusion defect on the ventilation/perfusion scan, are indicative of a pulmonary embolism (PE). A PE occurs when a blood clot lodges in a pulmonary artery, causing a blockage. In this case, the presence of deep venous thrombosis (DVT) and the patient's symptoms warrant the placement of an inferior vena cava (IVC) filter, which is a device that can prevent blood clots from reaching the lungs.