Final answer:
The most likely contributor to the increase in EMG signal during the last set of squats is an increase in fatigue. Muscle fatigue occurs when a muscle can no longer contract in response to signals from the nervous system.
Step-by-step explanation:
The most likely contributor to the increase in EMG signal during the last set of squats is an increase in fatigue. Muscle fatigue occurs when a muscle can no longer contract in response to signals from the nervous system. Factors such as reduced ATP reserves, lactic acid buildup, and imbalances in ion levels can all contribute to muscle fatigue and a decrease in force production.