Final answer:
Endorphins are released in the body after running a marathon, which reduces pain and discomfort.
Step-by-step explanation:
Melissa's lack of pain after running a marathon is likely the result of the release of endorphins. Endorphins are chemicals produced by the body that act as natural painkillers and create a feeling of euphoria. When Melissa completed the marathon, her body released endorphins, which helped reduce her pain and discomfort.