Final answer:
The three-base sequence on tRNA that pairs with mRNA during translation is called an anticodon, which is key for translating genetic information into proteins.
Step-by-step explanation:
The three-base sequence about midway along the sequence of tRNA that can bond to mRNA is called an anticodon. An anticodon is a specific three-nucleotide sequence in a tRNA molecule that pairs with a complementary codon in an mRNA molecule during the process of translation. In the context of the central dogma of molecular biology, it is crucial for translating the genetic information from the language of nucleic acids into the language of proteins. Each codon on the mRNA corresponds to a specific amino acid or a signal to terminate the protein synthesis, and the anticodon of tRNA is the key for the correct amino acid to be added to the growing polypeptide chain.