Question

What is the cause of medium-chain acyl-CoA dehydrogenase deficiency (MCAD deficiency), and what are its metabolic consequences?

A) Cause: Genetic mutation affecting the MCAD enzyme; Metabolic Consequences: Impaired metabolism of medium-chain fatty acids leading to hypoglycemia and potential life-threatening metabolic crisis.

B) Cause: High intake of medium-chain fatty acids; Metabolic Consequences: Enhanced energy production due to efficient fatty acid oxidation.

C) Cause: Insufficient intake of medium-chain fatty acids; Metabolic Consequences: Increased reliance on carbohydrate metabolism for energy, leading to hyperglycemia.

D) Cause: Disruption in insulin production; Metabolic Consequences: Elevated levels of circulating fatty acids, leading to obesity and insulin resistance.

Correct Answer: A) Cause: Genetic mutation affecting the MCAD enzyme; Metabolic Consequences: Impaired metabolism of medium-chain fatty acids leading to hypoglycemia and potential life-threatening metabolic crisis.

Answer 1

Medium-chain acyl-CoA dehydrogenase deficiency (MCAD deficiency) is caused by a genetic mutation affecting the MCAD enzyme. This mutation leads to impaired metabolism of medium-chain fatty acids, which can result in hypoglycemia and potentially life-threatening metabolic crisis.

Step-by-step explanation:

Cause: Genetic mutation affecting the MCAD enzyme;

Metabolic Consequences: Impaired metabolism of medium-chain fatty acids leading to hypoglycemia and potential life-threatening metabolic crisis.