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A(n) ___ is one in which the parents differ on any one trait.
Principle of ___.

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Final answer:

A monohybrid cross in genetics is a cross between parents that differ on any one trait, and it follows the Principle of Segregation where each parent contributes one factor for each trait to the offspring.

Step-by-step explanation:

In genetics, a monohybrid cross is one in which the parents differ on any one trait. The Principle of Segregation states that each parent gives one factor for each trait to an offspring. If a parent has one dominant and one recessive factor for a trait, then, on average, half the time the dominant factor will be passed on, and half the time the recessive factor will be passed on. This results in observable traits in the offspring that are a blend of the traits of their parents.

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