Final answer:
The claim that enzyme active sites have little specificity for substrates is false; enzymes are highly specific due to the unique characteristics of their active sites, operating like a lock and key.
Step-by-step explanation:
The statement that the active sites of enzymes have little specificity for substrates is not true. Enzymes are highly specific in their action due to the unique chemical environment of their active sites, which are uniquely suited to bind to specific substrates.
The physical and chemical properties at the active site include a combination of amino acids that create a selective affinity for its substrate(s), operating much like a lock and key. Some enzymes may demonstrate an induced fit mechanism, where the active site undergoes minor adjustments to accommodate similar substrates, yet this specificity remains quite high.