Question

Which conditions may result from immunoglobulin IgE antibodies on mast cells reacting with antigens? Select all that apply.

Correct 1
Asthma
Correct 2
Hay fever
3
Sarcoidosis
4
Myasthenia gravis
5
Rheumatoid arthritis
Clinical conditions such as asthma and hay fever are considered type I hypersensitive reactions that are mediated by a reaction between IgE antibodies with antigens. It results in the release of mediators such as histamines. Type IV hypersensitivity reactions such as sarcoidosis result from reactions between sensitized T cells with antigens. Myasthenia gravis results from a type II hypersensitivity reaction that occurs due to an interaction between immunoglobulin IgG and the host cell membrane. Rheumatoid arthritis is a type III hypersensitivity reaction that results from the formation of immune complexes between antigens and antibodies that results in inflammation.

Answer 1

Asthma and hay fever are conditions that can arise from the interaction of IgE antibodies with antigens, triggering type I hypersensitive reactions and releasing histamines that cause allergic symptoms.Hence, the correct answer is option 1 and 2.

Step-by-step explanation:

Conditions that may result from immunoglobulin IgE antibodies on mast cells reacting with antigens include asthma and hay fever, both of which are type I hypersensitive reactions. These reactions are mediated by the release of mediators such as histamines upon the cross-linking of IgE molecules on mast cells when exposed to allergens, leading to symptoms like sneezing, runny nose, and in more severe cases, airway constriction. Anaphylactic shock is a life-threatening manifestation of this type of hypersensitivity, requiring immediate treatment with epinephrine. Unlike type I hypersensitivity, sarcoidosis is related to type IV hypersensitivity, myasthenia gravis to type II, and rheumatoid arthritis to type III, none of which involve IgE antibodies on mast cells reacting with antigens.