Final answer:
Aldosterone regulation is mainly influenced by the renin-angiotensin system rather than ACTH, which primarily regulates the secretion of glucocorticoids like cortisol.
Step-by-step explanation:
False. Aldosterone is primarily regulated by the renin-angiotensin system, not directly by adrenocorticotropic hormone (ACTH). While ACTH does have some influence on the secretion of aldosterone, it is not the main regulator. The synthesis of aldosterone is stimulated by the renin-angiotensin system through changes in intracellular calcium levels. ACTH primarily stimulates the adrenal cortex to secrete glucocorticoids like cortisol.
The role of ACTH is significant in the adrenal gland's development and in the regulation of glucocorticoid synthesis and secretion. It facilitates the transport of cholesterol into the mitochondria for conversion into pregnenolone, which is a precursor to steroid hormones. However, the synthesis of mineralocorticoids like aldosterone is largely under the control of the renin-angiotensin system.