Final answer:
The organelle that would play the largest role in total cell destruction is the D. Lysosomes.
Step-by-step explanation:
Lysosomes are membrane-bound organelles that contain digestive enzymes. They function as the cell's recycling center, breaking down macromolecules and recycling their building blocks. In the case of total cell destruction, lysosomes would release their digestive enzymes and break down the cell's components.
For example, lysosomes can play a role in the destruction of pathogens. When a macrophage engulfs a pathogen, the lysosomes fuse with the phagosome containing the pathogen and release their enzymes, breaking down the pathogen. Therefore, the correct answer is D) Lysosomes.