Final answer:
Maria Irene Fornés is indeed a major Cuban American playwright, known for her avant-garde and influential theatrical work.
Step-by-step explanation:
The statement that Maria Irene Fornés is one of the major playwrights to come out of the Cuban American theatre is true. Fornés, an influential figure in the world of American avant-garde theater, was born in Cuba and later moved to the United States, where she made significant contributions to American drama. Her work is known for its exploration of social issues and complex character development, and she has been awarded nine Obie Awards for her outstanding achievements in the Off-Broadway theater.
Although historical and regional contexts, such as those exemplified by playwrights Severino Reyes and Eugene O'Neill, provide broader backdrop to theatrical evolution, Fornés stands distinguishably as one of the most innovative and interpretive Cuban American voices in the realm of dramatic writing and theater production.