Final answer:
The first federal tax on a domestically produced product, the federal liquor tax on whiskey, resulted in the Whiskey Rebellion of 1794.
Step-by-step explanation:
The first federal tax on a domestically produced product, specifically distilled spirits, led to an event known as the Whiskey Rebellion. In 1791, Congress had authorized a federal liquor tax as part of Alexander Hamilton's financial program, leading to unrest in rural areas, particularly in western Pennsylvania. Protests against the tax escalated to a point where President George Washington felt it necessary to send a large militia force to quell the rebellion, thereby asserting the authority of the national government.