Question

In order for influenza genome to be released into cytoplasm the internal pH of virus must be lower and this is facilitated by the M2 ion channel

A true
B false

Answer 1

The statement about the influenza virus relying on the M2 ion channel to lower the internal pH for genome release into the cytoplasm is true, as acidification through the M2 ion channel causes changes leading to viral genome release. Therefore, the most appropriate correct option is A.

Step-by-step explanation:

The question posed is regarding the release mechanism of the influenza virus genome into the cytoplasm of a host cell, which is facilitated by the lowering of the internal pH via the M2 ion channel. This statement is true. During the infection process, once the influenza virus is internalized by the host cell through endocytosis, the viral envelope is then exposed to the acidic environment of the endosome. The M2 ion channel of the influenza virus functions to transport hydrogen ions into the interior of the virion, leading to acidification. This drop in pH causes conformational changes that result in the fusion of the viral envelope with the endosomal membrane, thereby releasing the viral genome into the cytoplasm.