Final answer:
The regeneration of the action potential occurs in one direction because the inactivation gates of voltage-gated Na+ channels close in the node that has just fired an action potential.
Step-by-step explanation:
An action potential is propagated in one direction because the inactivation gates of voltage-gated Na+ channels close in the node, or segment, that has just fired an action potential. This prevents depolarization from spreading back towards previously opened channels, ensuring that the action potential propagates towards the axon terminals.