Final answer:
When working with a client with major depression who is irritable, abrasive, and uncooperative, the nurse should use the approach of firmness.
Step-by-step explanation:
When working with a client with major depression who is irritable, abrasive, and uncooperative, the nurse should use the approach of firmness. This means setting clear boundaries and expectations for the client's behavior while maintaining a professional and respectful demeanor. By being firm, the nurse can help provide structure and consistency which can be beneficial for individuals with major depression.