Final answer:
The term transdermal means going across or through the skin and is commonly used to describe a method of delivering medication directly into the bloodstream via the epidermis.
Step-by-step explanation:
The term transdermal is best defined as: D. going across or through the skin. In biology, this term is used to describe a route of administration for medications which directly passes across the skin to enter the bloodstream. This method leverages the selective permeability of the epidermal layer, which allows certain substances to penetrate it and be absorbed by the underlying layers. Notable applications of transdermal delivery include patches used for hormone replacement therapy, motion sickness, heart problems, and nicotine replacement in smoking cessation efforts.