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CRH promotes an overall ______ during pregnancy

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Final answer:

CRH promotes an overall state of increased hormonal activity during pregnancy, leading to heightened ACTH and cortisol levels, which are vital for fetal development and preparing the mother's body for breastfeeding.

Step-by-step explanation:

CRH, or Corticotropin-Releasing Hormone, promotes an overall state of increased hormonal activity during pregnancy. This hormone instigates a cascade that influences numerous physiological processes. It primarily triggers the anterior pituitary to release ACTH (adrenocorticotropic hormone), which in turn stimulates the adrenal glands to release glucocorticoids into the blood. These glucocorticoids, especially cortisol, play a crucial role in the development of the male reproductive system, protein synthesis for the fetus, and preparations for breastfeeding by the mother. The increased hormonal activity orchestrated by CRH also affects the mother's metabolism. For instance, the anterior pituitary enlarges and enhances hormone production, raising levels of thyrotropin and consequently increasing the thyroid hormone production that increases the maternal metabolic rate. This can intensify the pregnant mother's appetite and cause hot flashes. Increased parathyroid levels mobilize calcium from maternal bones for the growing fetus. Cortisol, a glucocorticoid released in response to ACTH, contributes significantly to weight gain during pregnancy by stimulating the catabolism of nutrients to maintain adequate fuel supplies and gradually increasing fat storage as a reserve for breastfeeding. Concurrently, prolactin stimulates the enlargement of the mammary glands, preparing for milk production post-delivery.

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