Final answer:
Frequent use of hand sanitizer instead of soap and water is likely to (a) lead to dry and potentially cracked hands. Brenda should use moisturizer to mitigate this effect and continue to use hand sanitizers with at least 60% alcohol content when soap and water are unavailable.
Step-by-step explanation:
The issue Brenda is most likely to face as a result of frequently using hand sanitizer instead of soap and water is hands that are dry to the point of cracking. Hand sanitizers often contain alcohol, which can be very drying to the skin, especially with repeated use.
The Centers for Disease Control and Prevention (CDC) recommends thorough handwashing with soap and warm water as the best practice for removing pathogens. However, when soap and water are not available, hand sanitizer with at least 60% alcohol is a good alternative. Brenda should consider using a moisturizer to prevent her hands from becoming too dry.