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How do we drive K+ back into the cell (4 ways)?

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Final answer:

K+ ions are driven back into the cell primarily by the sodium-potassium pump, facilitated diffusion through K+ channels, increased activity of the pump due to high ADP and phosphate, and secondary active transport mechanisms.

Step-by-step explanation:

To drive K+ back into the cell, several mechanisms are utilized:

  • The sodium-potassium pump (Na+-K+ ATPase), which actively transports two K+ ions into the cell while removing three Na+ ions for every ATP molecule hydrolyzed, thus maintaining the electrochemical gradient.
  • Facilitated diffusion through K+ channels allows K+ ions, which are highly concentrated inside the cell, to move down their concentration gradient when the channels are open. This is a passive process and does not require energy.
  • During times of high metabolic activity, an increase in intracellular ADP and phosphate can stimulate the sodium-potassium pump to restore the ionic concentrations by pumping Na+ out and K+ in more actively.
  • Secondary active transport mechanisms such as the Na+/K+ 2Cl- co-transporter, which uses the energy stored in the Na+ gradient to move K+ ions back into the cell, can aid in the accumulation of K+ within the cellular environment.
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