Question

What is the order of AMP degradation all the way to Urate?

Answer 1

The degradation of AMP to urate proceeds via the conversion of AMP to IMP, then to inosine, hypoxanthine, xanthine, and finally to urate, primarily catalyzed by xanthine oxidase.

Step-by-step explanation:

The degradation of AMP to urate involves several enzymatic steps. Here is the ordered process:

1. AMP is first converted to inosine monophosphate (IMP) by the enzyme adenylosuccinate synthetase, with the release of pyrophosphate (PPi).
2. IMP is then converted to inosine by the action of the enzyme IMP dehydrogenase.
3. Inosine is then degraded to hypoxanthine, releasing a ribose molecule.
4. Hypoxanthine is further oxidized to xanthine by xanthine oxidase.
5. Finally, xanthine is converted to urate, also by xanthine oxidase.

Urate is then eliminated from the body through the urine. Disorders such as Lesch-Nyhan syndrome can disrupt this process due to the lack of Hypoxanthine Guanine Phospho Ribosyl Transferase (HGPRT), leading to the accumulation of uric acid.