Final answer:
Creatinine clearance can be used to estimate the glomerular filtration rate (GFR), which represents a part of an individual's kidney function. This can be calculated using the formula CCr = (UxV) / B, where U is the concentration of creatinine in urine, V is the urine flow rate, and B is the concentration of creatinine in plasma.
Step-by-step explanation:
Creatinine clearance can be used to estimate the glomerular filtration rate (GFR), which represents a part of an individual's kidney function. GFR is the volume of fluid filtered from the kidney glomerular capillaries into the Bowman's capsule per unit time. Creatinine, a metabolite of creatine found in muscle, is freely filtered by the glomerulus and can be used to calculate creatinine clearance if values for creatinine concentration in urine, urine flow rate, and creatinine concentration in plasma are known.
The formula for creatinine clearance is:
CCr = (UxV) / B, where U is the concentration of creatinine in urine, V is the urine flow rate, and B is the concentration of creatinine in plasma.
Creatinine clearance is often corrected for the body surface area (BSA) and expressed compared to the average sized man as ml/min/1.73 m². This correction allows comparison of results between people of different sizes.